Suppression of morphine and cocaine self-administration in rats by a mixed mu antagonist-kappa agonist (N-CBM-TAMO) and a long-acting selective D 1 antagonist (AS-300)

Abstract

N-CBM-TAMO 2 was prepared by the same procedure as used for TAMO 1. It was found to be a short-term kappa agonist and a long-term mu antagonist. The benzazepine 12, (AS-300) was a potent selective D 1 antagonist. Both compounds suppressed cocaine and morphine self-administration in rats at doses which did not affect water consumption. The synthesis of N-CBM-TAMO ( 2) and AS-300 ( 12) is described. Both drugs block cocaine and morphine self-administration in rats.