Abstract
F. A. Green, B. Gustafsson and H.-E. Claesson. Suppression of leukotriene synthesis in human leukocytes by a urea extract of Bordetella pertussis: evidence for mediation by adenylate cyclase toxin. Toxicon 26, 1187–1192, 1988.—Incubation of human leukocytes with a urea extract of Bordetella pertussis led to inhibition of zymosan-induced leukotriene generation. The proteins in this extract are known to include an adenylate cyclase which suppresses certain defense mechanisms of leukocytes against bacterial invasion. The formation of leukotriene B 4 and leukotriene C 4, induced by serum-coated zymosan, was almost completely inhibited in the presence of 75 μg of ureaextracted proteins/ml cell suspension. This suppression by the bacterial urea extract was rapid, with the maximum effect occurring in the first min of incubation. The reduction in leukotriene generation was accompanied by a dramatic increase in intracellular cyclic AMP levels. Since leukotrienes are potent pro-inflammatory compounds, the present study indicates that Bordetella pertussis-induced suppression of leukotriene formation might be an important factor in the increased susceptibility to secondary bacterial infection, which occurs as a result of this disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
