Abstract
Background Oral carcinoma is the sixth most common cancer and is a serious public health problem, and tongue squamous cell carcinoma (TSCC) is the most common type of oral carcinoma. Kinesin family member 22 (KIF22), also called as kinesin-like DNA binding protein (KID), is a microtubule-based motor protein and binds to both microtubules and chromosomes, transporting organelles, protein, and mRNA. This research aimed at investigating the prognostic significance of KIF22 in TSCC. Patients and Methods. This retrospective research collected 82 paired tissues with TSCC. KIF22 protein expression level was detected by immunohistochemical staining. Suppression of KIF22 with shRNA in CAL-27 and SCC-15 cells was to observe cell proliferation in vitro and xenograft tumor growth in vivo. Results In TSCC tissues, the protein expression level of KIF22 was increased and correlated with tumor stage, clinical stage, and lymphatic metastasis (P=0.013, P=0.013, P=0.013, Conclusion KIF22 might play an important role in the progression of TSCC and could serve as a therapeutic target for TSCC.
Highlights
Oral carcinoma is the sixth most common cancer and is a serious public health problem [1, 2]
It is well known that tongue squamous cell carcinoma (TSCC) is the most common type of oral carcinoma, which has a high potential for locoregional invasion and nodal metastasis, so patients had a poor prognosis [6]. erefore, early detection of TSCC is more important
En, to further study the relationship between Kinesin family member 22 (KIF22) and cancer development, they analyzed KIF22 in several cancers in Oncomine database and confirmed that KIF22 had a high expression in ovarian cancer, lung cancer, and cervical cancer [17]. e above data suggested that KIF22 was overexpressed in several tumors and associated with poor prognosis
Summary
Oral carcinoma is the sixth most common cancer and is a serious public health problem [1, 2]. Recent reports estimated 49,670 patients suffered from oral carcinoma in the United States of America and 9,700 deaths in 2017 [3]. It is well known that TSCC is the most common type of oral carcinoma, which has a high potential for locoregional invasion and nodal metastasis, so patients had a poor prognosis [6]. Oral carcinoma is the sixth most common cancer and is a serious public health problem, and tongue squamous cell carcinoma (TSCC) is the most common type of oral carcinoma. In TSCC tissues, the protein expression level of KIF22 was increased and correlated with tumor stage, clinical stage, and lymphatic metastasis (P 0.013, P 0.034 and P 0.015, respectively). KIF22 might play an important role in the progression of TSCC and could serve as a therapeutic target for TSCC
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