Abstract
Monocytes or macrophages (MO) maybe induced to produce IL-1 by activators (e.g lipopolysaccharide endotoxin) that act directly or by antigens/mitogens that stimulate inducer lymphocytes (Ly) to release a lymphokinc (LK)that stimulates MO. Using guinea pigs (GP) rendered delayed hypersensitive to ovalbumin (OVA), we have investigated the role of spleen cells from normal, sensitized, and specifically desensitized (deS) GP in suppressing release of endogenous pyrogen (EP). from peritoneal c.xudatcs (PE) of sensitized GP when incubated with OVA in vitro. Cocultivation of all three sources of spleen cells with GP PE cells and OVA suppressed EP release as measured in the rabbit fever assay-especially with cells from deS GP This suppressor activity required both Ly and MO but was not modified by indomethacin. an inhibitor of prostaglandin release. This appears to be the first report of cell-mediated suppression of LK-mcdiatcd release of IL-1. an important modulator of the immune system.
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