Abstract
The humoral immune response against a thymus-dependent antigen, sheep red blood cells (SRBC), was suppressed in mice in-jected with levamisole i.v. at a few days before challenge with the antigen. The suppressive effect of levamisole was modified by an antigen dose, a drug dose and a timing of drug administration. The suppression of plaque-forming cell (PFC) response was observed at an optimal antigen dose of 2×108 SRBC while the augmentation was observed at a suboptimal antigen dose of 2×107 SRBC, at the same dose of the drug. However, no suppressive effect on serum antibody level was found throughout the experiments. Levamisole also shifted the peak of IgM-PFC earlier and the peak of IgG-PFC later respectively than in normal responses. Transfer of spleen cells from levamisole-treated donors to untreated recipients resulted in antigen specific suppression in the recipient immune response.These results suggest that, for the most part, an induction of antigen-specific suppressor cells in the spleen accounts for the suppression of humoral immunity by levamisole.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
