Abstract
The effects of three nitroso compounds (namely, nitrososarcosine, dibutylnitrosamine and diethylnitrosamine) on dimethylnitrosamine (DMN) demethylase activity were determined. Nitrososarcosine rapidly inhibited DMN demethylase activity, and induced statistically significant inhibitory effects at doses far below threshold levels for inhibition of aminopyrine demethylase. Nitrososarcosine, administered in vivo, induced non-competitive inhibition of DMN demethylase. Dibutylnitrosamine, diethylnitrosamine and even dimethylnitrosamine, itself, inhibited DMN demethylase activity at doses which had no effect on aminopyrine demethylase.
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