Abstract
The effects of three nitroso compounds (namely, nitrososarcosine, dibutylnitrosamine and diethylnitrosamine) on dimethylnitrosamine (DMN) demethylase activity were determined. Nitrososarcosine rapidly inhibited DMN demethylase activity, and induced statistically significant inhibitory effects at doses far below threshold levels for inhibition of aminopyrine demethylase. Nitrososarcosine, administered in vivo, induced non-competitive inhibition of DMN demethylase. Dibutylnitrosamine, diethylnitrosamine and even dimethylnitrosamine, itself, inhibited DMN demethylase activity at doses which had no effect on aminopyrine demethylase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
