Suppression of Helicobacter Pylori in Mice Intestine by Ingestion of Lactic Acid Bacteria in Yoghurt

Abstract

Helicobacter pylori (H. pylori) is a major cause of chronic gastritis and peptic ulcer. Antibiotics- based H. pylori eradication treatment is 90% effective, but it is expensive and can have side effects and antibiotic resistance. Probiotics costs less and are easily available. These studies were conducted to investigate the role of probiotics in the treatment of H. pylori infection. H. pylori were recovered from stool culture of peptic ulcer patients. Twenty albino wister mice weighing (25g -29g) were kept in 5cages, A to E (4 mice per cage). Faecal occult blood (FOB) test and viable bacterial count (VBC) were done on all the mice at different stages of the experiment. Animals in cages A to D were fed orally with different concentrations of H. pylori for 1week. Animals in cage E were fed with water as control. Finally the test mice were fed for another one week with yogurt which contains lactic acid bacteria then a retest was done. The results generated showed that the H.pylori can induce stomach ulcer and the Lactic acid bacteria in the yogurt suppressed the ulcer disease. Conclusively, this study has proven that Lactic acid bacteria in yoghurt can suppress Helicobacter pylori