Year-end Sale % OFF 
Abstract
Abstract Cisplatin, a commonly used broad spectrum chemotherapeutic drug, has been proven effective in the treatments of bladder, lung, ovarian, head and neck, testicular and breast cancers. One of the major side effects of this drug is its gastrointestinal toxicity, which includes severe nausea, vomiting and in case of rats bloating of the stomach and gastric ulceration. In case of rats, it manifests as bloating of the stomach and gastric ulceration since the rats don't have vomiting reflex. This has been attributed to hypocalcemia induced by cisplatin treatment which results in the suppression of acetylcholine and constitutive nitric oxide release inducing a bloating of the stomach. This has further been shown to induce an increase in the acid content of the stomach. There are no studies available on any changes of gastric protection after cisplatin treatment Gastrin has been shown to have gastroprotective effects against injury by maintaining the gastric mucosal integrity and gastric mucosal blood flow.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
