Abstract
Low‐dose γ‐irradiation of mouse embryonic fibroblast C3D2F1 3T3‐a cells caused Gl arrest along with G2 arrest and inhibition of replicative DNA synthesis. When the cells were cultured in the presence of inhibitors of poly(ADP‐ribose) polymerase [EC 2.4.2.30], such as 3‐aminobenzamide, benzamide and luminol, Gl arrest of C3D2F1 3T3‐a cells was suppressed and enhancement of G2 arrest was observed. In contrast, 3‐aminobenzoic acid, a non‐inhibitory analog of 3‐aminobenzamide, did not suppress Gl arrest following γ‐irradiation. These results suggest that the poly(ADP‐ribosyDation reaction is critical for the pathway of Gl arrest and is also involved in the pathway of G2 arrest.
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