Suppression of Free Fatty Acids by Oral Glucose in Patients with Cystic Fibrosis

Schnyder Marie-Angela,Tschopp Oliver,Zwimpfer Cornelia,Benden Christian,Schmid Christoph

doi:10.36959/647/493

Abstract

The oral glucose tolerance test (OGTT) is part of the routine management and readily detects impaired insulin secretion in the majority of adult patients with cystic fibrosis (CF). To assess an activity of endogeneous insulin on adipose tissue in these patients, we analyzed serum levels of insulin and free fatty acids (FFA) in response to oral glucose since glucose-induced insulin decreases FFA and thus, suppression of FFA reflects an insulin effect on adipose tissue.

Highlights

Cystic fibrosis (CF) is a multi-organ disease, characterized by chronic systemic inflammation and high-energy expenditure
Improved symptomatic treatment regimens and better outcomes following lung transplantation have contributed to an improved overall life expectancy in patients with CF over the last years [1]; disorders of glucose homeostasis increasingly emerge in clinical practice
The main goal of our study was to assess suppression of free fatty acids (FFA) during oral glucose tolerance test (OGTT); we measured adiponectin and leptin in patients with CF evaluated for lung transplantation

Summary

Introduction

Cystic fibrosis (CF) is a multi-organ disease, characterized by chronic systemic inflammation and high-energy expenditure. Exocrine pancreatic insufficiency often develops in the first year of life. Malnutrition and low body weight are common clinical findings in CF despite enzyme replacement therapy. Endocrine pancreas insufficiency appears later in course of disease. Improved symptomatic treatment regimens and better outcomes following lung transplantation have contributed to an improved overall life expectancy in patients with CF over the last years [1]; disorders of glucose homeostasis increasingly emerge in clinical practice. Up to half of adult patients with CF have CF related diabetes (CFRD). CFRD is related to increasing age, duration of exocrine pancreatic failure, and the Phe508del homozygous state.

Objectives

Methods

Results

Conclusion