Abstract
Objective To investigate the method and mechanism of immunologic tolerance induction via peritoneal on experimental autoimmune encephalomyelitis（EAE） Methods The animals were administrated with the soluble myelin basic protein (MBP) or transferred MBP sensitizing antigen presenting cells (MBP-APC) by intraperitoneal (I.p.). The clinical symptoms of EAE were observed. The delayed type hypersensitivity(DTH) and proliferative responses to MBP in vitro were tested. Results The incidence of EAE and severity of the disease were decreased in the I.p. Injection of MBP group and I.p. Injection of MBP-APC group contrast to the EAE group, In addition, DTH responses and the antigen specific proliferative responses to MBP in vitro were markedly suppressed. Conclusions EAE can be inhibited by intraperitoneal administration of MBP or MBP-APC via induction of specific immunologic tolerance. Key words: Myelin basic protein; Antigen-presenting cells; Experimental autoimmune encephalomyelitis; Intraperitoneal injection; Immunologic tolerance
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