Abstract
Wikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a W. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD.
Highlights
Atopic dermatitis (AD) is a chronic, relapsing inflammatory disease that is accompanied by representative symptoms, such as itching, redness, dry skin, and exudate
AD is a multifactor disorder caused by complex interactions between immunological, environmental, and genetic factors [4,5], and its hallmarks are markedly elevated serum immunoglobulin E (IgE) and interleukin-4 (IL-4) levels, and a damaged skin barrier function [6,7]
Wikstroemia species are still used as a herbal traditional medicines in China to treat various inflammatory conditions [17,24]
Summary
Atopic dermatitis (AD) is a chronic, relapsing inflammatory disease that is accompanied by representative symptoms, such as itching, redness, dry skin, and exudate. National Health and Nutrition Examination Survey (2016), the prevalence of AD in Korean adolescents was 25.1% [1]. Children and adolescents account for more than half of AD patients, though in recent years, the proportion of adult AD patients has increased [2,3]. AD is a multifactor disorder caused by complex interactions between immunological, environmental, and genetic factors [4,5], and its hallmarks are markedly elevated serum immunoglobulin E (IgE) and interleukin-4 (IL-4) levels, and a damaged skin barrier function [6,7]. Skin damage increases the susceptibility to penetration of the skin barrier by foreign substances or microorganisms, and because many of these exogenous stressors are potential allergens, skin penetration can result in allergic reactions
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