Abstract
The effect of purified aflatoxin B 1 on cell-mediated immunity (CMI) in broiler chicks was assessed using doses of 0.3 and 1 mg/kg feed from hatching to 6 weeks of age. Total lymphocyte and T lymphocyte counts and the 2,4-dinitrofluorobenzene skin sensitivity test, graft-versus-host reaction and nitroblue tetrazolium salt reduction tests were used to evaluate CMI. Both doses of aflatoxin B 1, including the apparently nontoxic dose of 0.3 mg/kg feed, caused a significant ( P < 0.05) decline in CMI. The functional activity of splenic macrophages was decreased significantly ( P < 0.05) by both doses of the toxin.
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