Abstract
Thirty‐nine dogs received renal allografts with simultaneous bilateral nephrectomy. Ten recipients were untreated, 15 were given daily subcutaneous injections of normal horse serum, normal cow serum or normal goat serum, and 14 received daily injections of horse antidog antilymphocyte serum (HALS), cow antidog antilymphocyte serum (CALS), or goat antidog antilymphocyte serum (GALS). The mean survival times of the untreated control animals and those receiving normal sera were 8·6 and 9·1 days respectively. No animal in these groups survived for more than 12 days. In the ALS‐treated dogs, a mean survival of 12·8 days was obtained with GALS, of 18·0 days with CALS and of 68·4 days with HALS.
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