Abstract
The effect of acute exposure to nitrogen dioxide (NO 2) on in vitro primary and secondary antibody responses to sheep red blood cells (SRBC) was studied in BALB c mice. After the in vivo exposure to 20 ppm NO 2 for 12 hr, spleen cells were separated and then cultured with SRBC. Cell reconstitution experiments indicated that in the primary antibody response B cells were more strongly suppressed than T cells, while in the secondary response suppression of primed T cells was greater than that of primed B cells.
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