Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes.

Abstract

SPECIFIC AIMSWe investigate whether resveratrol, a natural polyphenol compound found in various plants including grapes and their related products, could inhibit endothelial cell growth and act as an oral angiogenesis inhibitor. The antiangiogenic property of resveratrol was examined in several in vivo models including the mouse corneal model, the chick chorioallantoic membrane assay, a wound-healing model, and a tumor model.PRINCIPAL FINDINGS1. Inhibition of endothelial cell growth and MAP kinaseTo determine whether resveratrol, a phytoalexin and a polyphenol compound, could inhibit endothelial cell growth, we assayed resveratrol on bovine capillary endothelial (BCE) cells stimulated with fibroblast growth factor 2 (FGF-2). Resveratrol inhibited capillary endothelial cell growth in a dose-dependent manner. MAP kinase is a critical component in signaling pathways of endothelial cell proliferation. We examined the effect of resveratrol on FGF-2-induced activation of MAP kinases in BCE cells. It significant...