Abstract
Recently, we demonstrated the induction of immune tolerance in a murine model of cat allergy following systemic administration of a T cell epitope peptide (Campbell et al., J. Exp. Med 2009). In the current study we hypothesized that exposure to Der p 1 (major house dust mite [HDM] allergen)-derived peptides intranasally (local mucosal environment) could modulate markers of allergic airways disease in a murine model of HDM allergy.
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