Abstract
Modulation by Zn 2+ of ON and OFF responses of transient amacrine cells driven by red- and green-sensitive cones was investigated in isolated, superfused carp retina, using intracellular recording techniques. Zn 2+ selectively abolished the OFF response to red flash of the transient amacrine cells. This Zn 2+ effect was mimicked by GABA application and was blocked by bicuculline, indicating the involvement of GABA A receptors. Such differential modulation was observable neither in bipolar cells nor in sustained OFF amacrine cells. It is suggested that the Zn 2+ effect reported here might be due to a direct action of Zn 2+ on GABA A receptors of the transient amacrine cells.
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