Suppression by 5'-methylthioadenosine of histamine or leukotriene-induced contraction in isolated guinea pig tracheal rings.

Abstract

5′-Methylthioadenosine (MTA) is a naturally occurring purine nucleoside, which is produced from S-adenosylmethionine by several biosynthetic routes (1) (2) and metabolized by MTA Phosphorylase to S-methylthioribose-1-phosphate and adenine.(3) MTA has been shown to have numerous effects on cell metabolism and function(2) and recent interest has focused extensively on its anti-proliferative action.(4)(5) Snyder et al(6) suggested that MTA stimulates the adenosine receptor. There are many reports that, in the human subjects, many cells including tracheal smooth muscle cells, have the adenosine receptor.(7) The action of adenosine on tracheal muscle cells in vitro has been intensively investigated(8), but there are no reports concerning the action of MTA on tracheal smooth muscle preparations.KeywordsAdenosine ReceptorTracheal RingTracheal Smooth MuscleTracheal Smooth Muscle CellTracheal ContractionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.