Abstract
The secretion of calcitonin (CT) was studied in five patients with medullary thyroid carcinoma using a recently developed radioimmunoassay. All patients had elevated basal concentrations of plasma CT. Hypercalcemia, induced by calcium infusion in four patients, led to an increase in plasma CT. Hypocalcemia, induced by EDTA infusion in three patients, was followed by a decrease in plasma CT. Glucagon infusion led to an increase in plasma CT in three patients but to a marked decrease of plasma CT in one patient. These findings demonstrate that the secretion of calcitonin by this carcinoma is nonautonomous and can be suppressed as well as stimulated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
