Abstract
The aim of this work was to formulate Anthraquinone (AQ) loaded Chitosan (CS) nanoparticles using ionic gelation technique. The shape and size of the nanoparticles was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), zeta sizer and zeta potential. The drug release was studied and confirmed the sustained release of the drug. The cytotoxic effects were tested in-vitro against acute myeloid leukemia (HL-60) cells. Apoptosis investigations including cellular uptake, DNA fragmentation, and flow cytometry evaluation of the chitosan-anthraquinone nanoparticles was conducted. These results conclude that CS-AQ NPs have the ability to act against HL-60 cells.
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