Suppressing epileptic spike-and-wave discharges by extracranial alternating current stimulation

Abstract

Event Abstract Back to Event Suppressing epileptic spike-and-wave discharges by extracranial alternating current stimulation A. Berényi1*, M. Belluscio1 and G. Buzsáki1 1 Rutgers University, Center for Molecular and Behavioral Neuroscience, United States Direct electrical stimulation of non-specific higher order thalamic nuclei by deep brain stimulation proved to be effective to modulate the ongoing resonant activity in the reticulo-thalamo-cortical loop during epileptic seizures. Previous research in our laboratory demonstrated, that extracranially applied low frequency low intensity alternating current (AC) stimulation can efficiently modify neuronal activity at the single neuron level. The aim of this study was to attenuate absence epilepsy with extracranial AC stimuli. We recorded extracellular multiunit and field potentials in different cortical areas of freely moving rats. We have developed an automated online spike and wave discharge (SWD) detection and stimulus control system. We delivered pulses through galvanically isolated electrodes placed extracranially under the temporal muscles, triggered by the detected spikes and delayed to coincide with the wave segments of the SWDs. In some of the experiments we delivered continuous 1 Hz sinusoidal stimulation to estimate its direct effect on SWD spike amplitude. The continuous low frequency AC stimulation significantly modified the amplitude of SWDs. Bipolar stimulation with half-sinusoidal pulses substantially decreased the length of seizures compared to non-stimulated control epochs. These results suggest that the extracranial bipolar AC stimulation is an effective way to terminate epileptic seizures, without the negative side-effects of invasive intracerebral stimulation. Keywords: disorders, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Disorders Citation: Berényi A, Belluscio M and Buzsáki G (2011). Suppressing epileptic spike-and-wave discharges by extracranial alternating current stimulation. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00096 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. A. Berényi, Rutgers University, Center for Molecular and Behavioral Neuroscience, Newark, United States, drberenyi@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers A. Berényi M. Belluscio G. Buzsáki Google A. Berényi M. Belluscio G. Buzsáki Google Scholar A. Berényi M. Belluscio G. Buzsáki PubMed A. Berényi M. Belluscio G. Buzsáki Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.