Abstract
Clonidine at 1.0 μM significanty decreased 20 mM K + -evoked release of l -[ 3 H]noradrenaline (NA) from rat cerebral cortical slices preloaded with l -[ 3 H]NA. Inhibitory effects of clonidine, however, were not observed in slices pretreated with 20 μg/ml pertussis toxin, an islet-activating protein, together with NAD and adenosine triphosphate. It is suggested that the inhibitory guanine nucleotide-binding protein (Ni) could be involved in α 2 -adrenoceptor-mediated inhibition of NA release from nerve terminals in the central nervous system.
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