Supportive Family Environments can Improve Treatment Compliance, Social Cognition, Brain Activity in Patients with Schizophrenia - A Pilot Study

Abstract

Objectives: Supportive family environments can improve the prognosis of patients with schizophrenia by enhancing treatment compliance, social cognition, and functional brain alterations. This study aimed to investigate the impact of supportive family environments on treatment compliance, social cognition, and the associated brain activity features in patients with schizophrenia. Methods: Patients with schizophrenia (n=40) and healthy controls (n=25) were recruited, and divided into two groups, including (1) supportive family environment group and (2) non-supportive (poor) family environment group. The Adherence Rating Scale (MARS) was adopted to assess treatment compliance. The Basic Empathy Scale (BES) and Social Attribution Task-Multiple Choice were used to assess social cognition. The Positive and Negative Symptoms Scale (PANSS) was used to assess the severity of schizophrenic symptoms. gFCD was used to assess functional brain alterations. Results: Compared to patients with non-supportive family environments, patients with supportive family environments showed better treatment compliance [8.5 (1.2) vs. 4.5 (1.5), P