Abstract
Long non-coding RNAs and microRNAs control gene expression to determine central nervous system development and function. Neuronal growth regulator 1 (NEGR1) is a cell adhesion molecule that plays an important role in neurite outgrowth during neuronal development and its precise expression is crucial for correct brain development. The data described here is related to the research article titled “A long non-coding RNA, BC048612 and a microRNA, miR-203 coordinate the gene expression of Neuronal growth regulator 1 (NEGR1) adhesion protein” [1]. This data article contains detailed bioinformatics analysis of genetic signatures at the Negr1 gene locus retrieved from the UCSC genome browser. This approach could be adopted to identify putative regulatory non-coding RNAs in other tissues and diseases.
Highlights
Supporting data for characterization of non-coding RNAs associated with the Neuronal growth regulator 1 (NEGR1) adhesion protein
Neuronal growth regulator 1 (NEGR1) is a cell adhesion molecule that plays an important role in neurite outgrowth during neuronal development and its precise expression is crucial for correct brain development
The data described here is related to the research article titled “A long non-coding RNA, BC048612 and a microRNA, miR-203 coordinate the gene expression of Neuronal growth regulator 1 (NEGR1) adhesion protein” [1]
Summary
This data provides a comprehensive in silico analysis of the genetic signatures and expression pattern of long non-coding RNAs associated with the Negr gene. This data is useful in understanding the regulatory relationship between non-coding RNA gene expression and Negr gene expression. The methodology provided can be used to postulate regulatory relationships between long noncoding RNAs and proximal genes This approach could be adopted to identify putative regulatory non-coding RNAs in other tissues and diseases which could be evaluated with further functional studies. The data in this article describes the initial in silico analysis carried out on the Negr gene locus for genetic signatures and expression patterns of long non-coding RNAs in proximity to the Negr gene [1] The proposed interaction between the BC048612 lncRNA and microRNA203 were validated using qPCR (Fig. 3)
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