Abstract
Many works of both Ukrainian scientists and foreign are devoted to the study of the prevention of iron deficiency anemia in piglets as one of the most common non-communicable diseases of pigs. However, the development of new effective antianemic drugs is still relevant today. We have previously proposed a scheme for the prevention of iron deficiency anemia, based on intramuscular parallel administration of solutions of iron (IV) clatrochelate and cyanocobalaminе to pregnant sows 14 and 7 days before the expected farrowing. This scheme was effective in the absence of stillbirth and clinical signs of anemia in piglets. The aim of our next study was to investigate the content of iron in the milk of sows using iron (IV) clatrochelate during pregnancy. To achieve this goal, 2 groups of sows (hybrids of Landrace and Great White breeds) were formed during their pregnancy and kept with suckling piglets - control and experimental, 5 animals in each. Sows in the experimental group were injected twice (14 and 7 days before expected farrowing) with 10 ml of 10% iron (IV) clatrochelate solution and cyanocobalaminе solution (at the dose recommended by official instructions) twice during pregnancy. Sows of the control group were injected with isotonic sodium chloride solution in conventional doses. During the experiment, the sows of the experimental group during pregnancy (after drug administration) and during the feeding of piglets did not differ in behavior and general condition from the sows of the control group. The study of the dynamics of hemoglobin and morphological parameters of the blood of sows in the control and experimental groups did not reveal significant differences. The content of iron in colostrum / milk of sows of the experimental group during the first seven days after administration was significantly higher compared to the control: 1 day 1.5 times, 4 days 2.1 times and 7 days 2.8 times. Therefore, the proposed scheme for the prevention of iron deficiency anemia in piglets is highly efficientand based on the intake of iron with colostrum/milk of sows. Key words: anemia, injection, macrobicyclic complex, prophylaxis, pigs, cyanocobalaminе.
Highlights
Based upon a more detailed analysis of the published data on the nerve supply of primary and secondary lymphatic organs in mammals and birds [1, 5, 6, 9, 10, 17, 18], it is evident that more precise information on the adrenergic innervation of the spleen is relatively plentiful
They border all its filial branches in the form of carrier nerve plexuses and more delicate plexuses consisting mainly of the preterminal and ter− minal fibres (Fig. 1). These fine plexuses lie in close contact with the external side of the muscular media layer and are sometimes called “adventitial plexuses” BuChE−positive perivascular nerve profiles border ar− teries and arterioles that pass through the spleen partly within the fibrous trabeculae and partly in the periarte− rial lymphatic sheath (PALS)
From these plexuses more fine nerve fibres radiate into the surrounding periarterial lymphatic sheath (PALS), and in the vicinity of the white pulp, as well as in the inner region of the marginal zone within PALS, they can be seen most often in the marginal zone between the red and white pulp
Summary
Based upon a more detailed analysis of the published data on the nerve supply of primary and secondary lymphatic organs in mammals and birds [1, 5, 6, 9, 10, 17, 18], it is evident that more precise information on the adrenergic innervation of the spleen is relatively plentiful. The published data about AChE−positive innervation of the spleen in mammals are somewhat controversial, because more inves− tigators have been unable to find AChE−positive nerve fibres in the parenchyma of the organ [8, 13, 15, 16], while the others have described only a small amount of nerve fibres near the hilus [7]. For this discrepancy in the published data about cholinergic innervation, we have examined the BuChE−positive innervation of the spleen in rabbits, because the published data about BuChE−positive nerve supply of this organ in these are only incomplete
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