Abstract
<p>Table S1. Mouse plasma protein binding profile of MU380 and SCH900776. Table S2. IC50 determination of main P450 cytochrome isoforms in human liver microsomes. Table S3. A) Evaluation of MU380 and SCH900776 disappearance with time in the presence of human liver microsomes. B) Human microsomal stability intrinsic clearance data for MU380 and SCH900776. Table S4. Statistical analysis of dose response curves for cell lines indicated in the Figure 3A. Table S5. Statistical analysis of dose response curves for cell lines indicated in the Figure 3B. Table S6. Distribution properties of SCH900776 and MU380 obtained using Caco-2 permeability drug assay. Table S7. Pharmacokinetics of SCH900776 and MU380. Table S8. Residual kinase activities for SCH900776, MU380, and MU378 (1 μmol/L) measured in a panel of 207 human kinases (Eurofins KinaseProfiler service). Table S9. The median survival time. Table S10. Log-rank (Mantel-Cox) test, used to assess the statistical differences in survival curves among the groups. Table S11. Available data for mutational status of the cell lines included in the screen were extracted from Cancer Cell Line Encyclopedia (CCLE) database.</p>
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