Supplementation with Spirulina platensis Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training.

Paula Benvindo Ferreira,Glêbia Alexa Cardoso,Anderson Fellyp Avelino Diniz,Maria da Conceição Correia Silva,Francisco Fernandes Lacerda Júnior,Alexandre Sérgio Silva,Bagnólia Araújo da Silva

doi:10.3390/nu13113763

Paula Benvindo Ferreira, Glêbia Alexa Cardoso + Show 5 more

Open Access

https://doi.org/10.3390/nu13113763

Copy DOI

Journal: Nutrients	Publication Date: Oct 24, 2021
Citations: 6	License type: CC BY 4.0

Affiliation: Universidade Federal da Paraíba

Abstract

Strength training increases systemic oxygen consumption, causing the excessive generation of reactive oxygen species, which in turn, provokes oxidative stress reactions and cellular processes that induce uterine contraction. The aim of this study was to evaluate the possible protective effect of Spirulina platensis (SP), an antioxidant blue algae, on the contractile and relaxation reactivity of rat uterus and the balance of oxidative stress/antioxidant defenses. Female Wistar rats were divided into sedentary (CG), trained (TG), and T + supplemented (TG50, TG100) groups. Reactivity was analyzed by AQCAD, oxidative stress was evaluated by the malondialdehyde (MDA) formation, and the antioxidant capacity was measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Strength training increased contractile reactivity and decreased the pharmaco-mechanical component of relaxing reactivity in rat uterus. In addition, training decreased oxidation inhibition in the plasma and exercise increased oxidative stress in the uterine tissue; however, supplementation with algae prevented this effect and potentiated the increase in antioxidant capacity. Therefore, this study demonstrated that food supplementation prevents changes in reactivity and oxidative stress induced by strength training in a rat uterus, showing for the first time, that the uterus is a target for this exercise modality and antioxidant supplementation with S. platensis is an alternative means of preventing uterine dysfunction.

Highlights

Regular training has numerous beneficial effects on human health through the induction of homeostatic adaptations in different physiological systems such as the cardiorespiratory and muscle systems [1]
In the group submitted to strength training (GT), there was a reduction in potency and an increase in contractile efficacy in response to KCl
We investigated the modulation of contractile reactivity in the uterus of rats by strength training and in the association of dietary supplementation with training, 4

Summary

Introduction

Regular training has numerous beneficial effects on human health through the induction of homeostatic adaptations in different physiological systems such as the cardiorespiratory and muscle systems [1]. The magnitude of the effect of a specific training regime can vary significantly between individuals, as well as in individuals undergoing training who may not respond as expected [2]. This is due to factors such as the characteristics of the training regime, environmental conditions and individual factors, such as habitual physical activity, previous physical fitness level, genetics, psychological factors, age and sex [3]. In the past few decades, women have become increasingly physically active and evidence demonstrates that physical training can increase self-esteem, cardiorespiratory fitness, ovulation, and menstrual regularity while decreasing insulin resistance and body fat [4]. The uterus should definitely be considered an important organ, making it an attractive target for exercise

Objectives

Methods

Results

Discussion

Conclusion