Abstract
The possible mechanism is involved in the effects of Spirulina platensis on vascular reactivity. Animals were divided into sedentary group (SG) and sedentary groups supplemented with S. platensis at doses of 50 (SG50), 150 (SG150), and 500 mg/kg (SG500). To evaluate reactivity, cumulative concentration-response curves were constructed for phenylephrine and acetylcholine. To evaluate the involvement of the nitric oxide (NO) pathway, aorta tissue was preincubated with L-NAME and a new curve was then obtained for phenylephrine. Biochemical analyses were performed to evaluate nitrite levels, lipid peroxidation, and antioxidant activity. To contractile reactivity, only SG500 (pD2 = 5.6 ± 0.04 vs. 6.1 ± 0.06, 6.2 ± 0.02, and 6.2 ± 0.04) showed reduction in phenylephrine contractile potency. L-NAME caused a higher contractile response to phenylephrine in SG150 and SG500. To relaxation, curves for SG150 (pD2 = 7.0 ± 0.08 vs. 6.4 ± 0.06) and SG500 (pD2 = 7.3 ± 0.02 vs. 6.4 ± 0.06) were shifted to the left, more so in SG500. Nitrite was increased in SG150 and SG500. Lipid peroxidation was reduced, and oxidation inhibition was increased in all supplemented groups, indicating enhanced antioxidant activity. Chronic supplementation with S. platensis (150/500 mg/kg) caused a decrease in contractile response and increase in relaxation and nitrite levels, indicating greater NO production, due to decreased oxidative stress and increased antioxidant activity.
Highlights
Nowadays, the practice of herbal medicine involves the use of more than 53,000 species of natural products for primary health care [1]
Supplementation with S. platensis at doses of 50 and 150 mg/kg did not alter the contractile reactivity of the rat aorta to PHE compared with saline group (SG)
Supplementation with S. platensis at doses of 50, 150, and 500 mg/kg did not alter contractile reactivity to PHE in the rat aorta without functional endothelium compared to SG (Figure 2)
Summary
The practice of herbal medicine involves the use of more than 53,000 species of natural products for primary health care [1]. Several of these species are of aquatic origin and have drawn the attention of pharmaceutical research, considering that the aquatic environment is rich in natural resources and many biologically active compounds [2]. One group of aquatic organisms that has been highlighted due to its diverse biological activities is the blue-green algae They belong to the phylum Cyanobacteria and family Spirulinaceae and are among the photosynthetic prokaryotes found in aquatic ecosystems. These microalgae were used as traditional food by some Mexican, African, Native American, and Oriental people [3]
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