Abstract
Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 h thereafter for 24 h, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated the muscle pain felt after the competition (6.8 ± 1.5 and 5.7 ± 2.2 a.u., p = 0.035) and the loss of jumping performance (9.4 ± 11.5 and 3.9 ± 5.2%, p = 0.036; p = 0.034) and mechanical impulse (p = 0.038) 24 h later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p < 0.05). In conclusion, a single dose of 140 mg Zynamite® combined with 140 mg of quercetin, administered one hour before competition, followed by three additional doses every eight hours, attenuates muscle pain and damage, and accelerates the recovery of muscle performance.
Highlights
Prolonged or unusual exercise, when involving eccentric muscle contractions, may cause muscle damage [1]
Polyphenol supplementation had no significant effects on running time in the 10 km race (3392 ± 561 and 3409 ± 479 s, for the placebo and polyphenol group, respectively, p = 0.91) (Table 4), even after accounting for the 5 km mark recorded before the competition (p = 0.24)
This study has shown that a single dose of 140 mg Zynamite® combined with a similar amount of quercetin, taken one hour before exercise eliciting muscle damage, followed by three additional doses every 8 h (420 mg/24 h of each polyphenol during the recovery period), attenuates the pain and the muscle damage elicited by the race and accelerates the recovery of muscle performance
Summary
When involving eccentric muscle contractions, may cause muscle damage [1]. Zynamite® , a mango leaf extract rich in the natural polyphenol mangiferin, and quercetin have antioxidant and anti-inflammatory properties [7,8,9,10], which may prevent EIMD and facilitate recovery [11]. These two polyphenols have not been studied in combination and the effect of quercetin has been only assessed after chronic administration and with large daily doses (∼1000 mg), which could impair exercise performance or blunt part of the adaptations to training [12]. The risk and magnitude of EIMD is exacerbated when muscle contractions are performed at longer muscle length, faster angular velocity, and with higher forces [2]
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