Abstract
Lactobacillus plantarum K68 (isolated from fu-tsai) and fruit-vegetable ferment (FVF) have been tested for antidiabetic, anti-inflammatory, and antioxidant properties in a rat model of insulin resistance, induced by chronic high fat-fructose diet. Fifty rats were equally assigned into control (CON), high fat-fructose diet (HFFD), HFFD plus K68, HFFD plus FVF, and HFFD plus both K68 and FVF (MIX) groups. Respective groups were orally administered with K68 (1 × 109 CFU/0.5 mL) or FVF (180 mg/kg) or MIX for 8 weeks. We found that HFFD-induced increased bodyweights were prevented, and progressively increased fasting blood glucose and insulin levels were reversed (P < 0.01) by K68 and FVF treatments. Elevated glycated hemoglobin (HbA1c) and HOMA-IR values were controlled in supplemented groups. Furthermore, dyslipidemia, characterized by elevated total cholesterol (TC), triglyceride (TG), and low-density lipoproteins (LDLs) with HFFD, was significantly (P < 0.01) attenuated with MIX. Elevated pro-inflammatory cytokines, interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), were controlled (P < 0.01) by K68, FVF, and MIX treatments. Moreover, decreased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were substantially (P < 0.01) restored by all treatments. Experimental evidences demonstrate that K68 and FVF may be effective alternative medicine to prevent HFFD-induced hyperglycemia, hyperinsulinemia, and hyperlipidemia, possibly associated with anti-inflammatory and antioxidant efficacies.
Highlights
The major recent challenge in medical or food science in developed/developing counties is to combat against the diet related disorders, especially diseases connected to insulin resistance (IR) syndrome
Evidences from our study clearly demonstrated that supplementation of L. plantarum K68 and fruit-vegetable ferment (FVF) along with high fat-fructose diet (HFFD) significantly attenuated the obesity, hyperglycemia, hyperinsulinemia, and hyperlipidemia
Our study demonstrated that L. plantarum K68 and fermented fruit-vegetables supplements contribute to decrease the hyperglycemia, hyperinsulinemia, and hyperlipidemia in HFFD-fed rats
Summary
The major recent challenge in medical or food science in developed/developing counties is to combat against the diet related disorders, especially diseases connected to insulin resistance (IR) syndrome. IR represents a cluster of metabolic disorders, including obesity, glucose intolerance, and predisposes to type 2 diabetes [1, 2]. Chronic high fat intake has been proved as a key responsible factor for metabolic syndrome [5]. High fructose consumption progresses to dietary model of type 2 diabetes that is associated with obesity, IR, hyperglycemia, and dyslipidemia [2]. Intake of either fat or fructose diet has been shown to trigger the free radicals or reactive oxygen species (ROS) production, ruining the antioxidant and inflammatory systems [5,6,7]
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