Supplementation of Natto-Pressed Candy (CHOLESWISE Pressed Candy) Improved Blood Pressure: A Randomized, Controlled Trial

Abstract

The application of plant-based health supplements for reducing blood pressure represents a natural and comprehensive approach involving various botanical extracts aimed at maintaining cardiovascular health. Commonly found in these supplements, such as natto, Haematococcus pluvialis, garlic, and linseed oil, are believed to provide certain benefits in lowering blood pressure. However, comprehensive clinical research on their combined usage must still be available. This trial aimed to explore whether Natto-pressed candy (product name: CHOLESWISE Pressed Candy) can regulate blood pressure. First, using Natto-pressed candy (0.0625%, 0.125%) treated smooth muscle cells and vascular endothelial cells, and then analyzed vascular health genes. Second, the trial recruited 60 subjects with blood pressure (SBP >120 mmHg / DBP >80 mmHg). Subjects took 2 tablets of pressed candy daily for 8 weeks, and blood pressure and blood samples were collected at weeks 0, 4, and 8. The results showed that Natto-pressed candy can increase beneficial vascular health genes, and decrease harmful vascular health genes compared to mock group in vitro. In clinical trial, the average systolic blood pressure was significantly decreased by 9 mmHg compared to baseline (week 0), and significantly decreased by 6.4 mmHg compared to the placebo group. The fibrinogen concentration in the blood was significantly decreased by 13.4% compared to baseline (week 0). Natto-pressed candy, which included natto, Haematococcus pluvialis, garlic, and linseed oil, reduced blood pressure, fibrinogen and regulated vascular health genes.