Abstract
Calcium channel blockers (calcium antagonists) are a diverse group of drugs that are currently approved for the treatment of hypertension and angina pectoris. They share a similar activity, despite their dissimilar chemical structures: attenuation of the cellular influx of calcium. Since the transmembrane flux of calcium is a common signalling system for cellular biochemical processes, calcium antagonists may influence numerous cellular functions. Many of these physiological processes are important in mediating responses to vasoconstrictor substances, such as may be involved in cyclosporin-mediated hypertension, nephrotoxicity and delayed graft function.
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