Abstract
The objective of this study was to see how supplementation with Garcinia mangostana extract (GME) and Vasconcellea pubescens extract (VPE) affected exercise performance and oxidative stress in intensely exercised rats. Twenty-five male rats were used in the study. Rats were divided into five groups: normal, stress oxidative control, combination GME:VPE (50:50), combination GME:VPE (75:25), and combination GME:VPE (25:75) groups. The antioxidant activity of a single extract from the literature was used to make the percentage comparison between extracts. The chronic exercise was done by swimming at 10 m/day for two weeks. Rats in the acute exercise groups were treated by swimming on the pail containing water. Blood samples were collected from the orbital sinus to determine hematological parameters. Liver tissue samples for the analysis of malondialdehyde (MDA) and glutathione (GPx) markers. Data analysis was performed statistically using One Way ANOVA. The combination of GME and VPE was shown to be effective in reducing oxidative stress and increasing MDA and GPx enzyme activity. The administration of both extracts also showed changes in the hematological profile.
Highlights
Oxidative stress is defined as a disruption in the balance of reactive oxygen species production and antioxidant defenses (Betteridge, 2000)
Extraction Two kilograms dried of mountain papaya fruit and garcinia mangostana peel extracted by maceration method using ethanol 70% as solvent (1:3)
The single-dose was chosen based on previous studies' oxidative stress activity, which showed that garcinia mangostana peel extracts showed activity at a dose of 400 mg/kg (Arsana et al, 2013), and mountain papaya fruit extract at 240 mg/kg (Sasongko et al, 2018)
Summary
Oxidative stress is defined as a disruption in the balance of reactive oxygen species production and antioxidant defenses (Betteridge, 2000). The increase of free radical formation due to external influences can make the defense system less effective so it requires the intake of antioxidants from the outside. Nonessential antioxidants such as α-tocopherol, β-carotene, vitamin C (Grażyna et al, 2017; Olale et al, 2019) and flavonoids can be obtained from various types of vegetables and fruits (JiménezAguilar and Grusak, 2017). Mangosteen rind contains various secondary metabolites such as xanthone, mangostin, tannin, and flavonoids (Im et al, 2017) These compounds are thought to play a role in determining the amount of antioxidants activity (Hassan et al, 2015). A combination of mountain papaya and Garcinia mangostana ethanol extracts was investigated thought to have a synergistic effect as an antioxidant. Not all combinations of substances have a synergistic impact
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