Supplementation of Enteric-coated Ginger and Garlic Essence Tablet Improved Blood Lipid Profile in Rats Fed High-fat Diet and Hyperlipidemic Subjects

Abstract

To evaluate the hypolipidemic effect, enteric-coated ginger and garlic essence tablet was produced through the modern pharmaceutical manufacture technique. Rats fed high-fat diet were developed to moderate degree of hyperlipidemia. Experimental group was assigned to orally expose to three different doses of essence tablet for 30 consecutive days. Through the course of treatment serum total cholesterol (TCh) and triglyceride (TG) in 220 mg/kg BW group were significantly lower than that in control group. In addition, a double blind, placebo-controlled clinical trial was conducted on patients with newly diagnosed exclusive hyperlipidemia. Participants were randomly divided into two groups of 52 cases each. Experimental group received one piece of ginger and garlic essence tablet twice daily. At the end of the 30-day trial, TCh and TG in experimental group were significantly lower than the baseline, respectively. Moreover, TCh and TG in experimental group were significantly lower than that in placebo group. Specifically the mean changes of TCh and TG in experimental group were extreme significantly higher than those in placebo group. These data implied that enteric-coated ginger and garlic tablet remarkably improved blood lipid profile in rats fed high-fat diet and hyperlipidemic subjects.