Supplementation of Carrot Incorporated Paneer Attenuates Diabetes through its Antioxidant Potential in Streptozotocin-Nicotinamide-Induced Diabetic Rats

Abstract

Background: The ideal medications for diabetes mellitus (DM) should have less or no adverse effects, thus screening on the antidiabetic activities of plant-based products is in urgent need. Paneer is the fundamental nutritious and complete native dairy products, and natural products incorporated paneer has greatly increased its therapeutic potential.Objective: The current study was undertaken to explore the effects of carrot incorporated paneer (CIP) on blood glucose, body weight, insulin, and enzymatic antioxidants such as superoxide dismutase, catalase, glutathione (GSH) peroxidase, and reduced GSH in streptozotocin (STZ) and nicotinamide (NAD)-induced diabetes in rats.Materials and Methods: Diabetic rats were orally supplemented with CIP (200 mg/kg body weight/day) for 1 month and the effects were compared with gliclazide (5 mg/kg body weight/day).Results: Supplementation of CIP or gliclazide was resulted in noteworthy diminish in the levels of blood glucose and increase in body weight and insulin levels. STZ-NAD administration caused the diminution in enzymatic antioxidant activities in diabetic rats and supplementation with CIP predominantly enhanced the levels of antioxidant enzymes in diabetic rats when contrasted to diabetic group.Conclusion: Hence, the results suggested that CIP has the potential antioxidant capability and may be believed as an efficient curative constituent for the management of DM.