Abstract

The present study on supplementation of Cantharanthus roseus leaf extract (CRLE) to rats suffer from hypercholesterolemia was aimed to determine whether it has property as an anti-inflammatory substance assessed from concentrations of tumor necrosis factor-α (TNF- α) and Interleukin-6 (IL-6) in the blood serum. A randomized pre-test and post-test design was employed, using 4 weeks old Wistar derived-rats at body weight ranging from 70 – 72 gram. The rats were initially fed with normal rat pellets for 1 month followed by high fat ration for 6 weeks in order to induce hypercholesterolemia condition. Then they were divided into 5 groups according to various treatments applied as follows. Group 1: control –

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