Abstract
Background: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol®, Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS). Methods: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol®, two capsules per day (100 mg/d of oleuropein and 20 mg/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined. Results: Significant reductions (p < 0.0001) in SBP/DBP (13 ± 10/7.1 ± 6.6 mmHg) were observed and similarly in pre-diabetic and diabetic patients. Improvements in SBP/DPB were independent of age and gender but greater for elevated baseline SBP/DBP. Tensiofytol® supplementation also significantly improved markers of MetS, with a decrease of TG (11%), WC (1.4%) and FG (4.8%) and an increase of HDL-C (5.3%). Minor side effects were reported in 3.2% patients. Conclusions: This real-life, observational, non-controlled, non-randomized pilot study shows that supplementation of a combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.
Highlights
Hypertension is a major component of the metabolic syndrome (MetS), a common cluster of five pre-morbid metabolic-vascular risk factors or disorders associated with increased cardiovascular morbidity, fatty liver disease and risk of cancer
They enrolled a total of 663 consecutive patients of their practice who basically met the following inclusion criteria—age between 18 and 80 years, suffering from borderline hypertension (SBP of 130 to 139 mmHg and/or diastolic blood pressure (DBP) of 85 to 89 mmHg) or from Grade 1 hypertension (SBP range of 140–159 mmHg and/or DBP 90–99 mmHg), untreated or under treatment with any blood pressure (BP)-lowering medication(s)
48.7% of patients suffered from Grade 1 hypertension and 5.1% from borderline tension
Summary
Hypertension is a major component of the metabolic syndrome (MetS), a common cluster of five pre-morbid metabolic-vascular risk factors or disorders associated with increased cardiovascular morbidity, fatty liver disease and risk of cancer. People with MetS meet three or more of the following criteria—enlarged waist circumference (WC) > 88 cm (women) or > 102 cm (men); raised fasting triglycerides (TG) ≥ 150 mg/dL; low high-density lipoprotein cholesterol (HDL-C) < 40 mg/dL (men) or < 50 mg/dL (women); fasting blood glucose (FG) ≥ 100 mg/dL; and/or raised systolic blood pressure (SBP)/diastolic blood pressure (DBP) ≥ 130/≥ 85 mmHg (or ongoing drug treatment for hypertension) [1]. The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol® , Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS). Results: Significant reductions (p < 0.0001) in SBP/DBP (13 ± 10/7.1 ± 6.6 mmHg) were observed and in pre-diabetic and diabetic patients
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