Abstract
This study aimed to assess the effects of fish oil plus all-trans retinoic acid (ATRA) on lipid metabolism and fat accumulation. Forty male C57BL/6J mice were divided into four groups; the FO, SO, FR, and SR groups were provided with fish oil, soybean oil, fish oil with ATRA, and soybean oil with ATRA, respectively. After 16 weeks, the SR and FR groups had significantly lower body weight than the SO and FO groups. Moreover, the FR group had the lowest reproductive white adipose tissue weight, liver triglyceride level, and acetyl-CoA carboxylase activity and the highest acyl-CoA oxidase and catalase activities among all groups. Additionally, fish oil alone also showed significantly improved serum and liver lipid profiles. ATRA in combination with fish oil or soybean oil both had significantly decreased reproductive white adipose tissue and increased expression of liver peroxisome proliferator-activated receptor δ and retinoic acid receptor α. ATRA may inhibit weight gain and fat accumulation, thus preventing obesity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
