Supplementary Methods and Figure Legends and Figures from The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis

Abstract

<p>PDF file, 840K, Supplementary Materials and Methods, Supplementary Figure Legends and Supplementary Figures Supplementary Figure S1. Transcriptional profile of ADM expression in paired patient-matched normal and carcinoma tissues. Supplementary Figure S2. CLR expression in tumor cells and tumor vessels in renal carcinoma. Supplementary Figure S3. High CLR expression in tumor cells and tumor vessels in renal cancers compared to normal tissues and its association with histology Supplementary Figure S4. Terminal glycosylation of CLR expressed in renal tumor tissues and cell lines. Supplementary Figure S5. Expression of ADM and RAMPs 1, 2 and 3 mRNAs in cell lines and renal tissues was analyzed by reverse transcriptase PCR (RT-PCR). Supplementary Figure S6. High CLR expression in tumor cells and tumor vessels in renal tumors compared to normal tissues and its association with T stage.</p>