Supplementary Information from Enhanced Delivery of SN-38 to Human Tumor Xenografts with an Anti-Trop-2–SN-38 Antibody Conjugate (Sacituzumab Govitecan)

Abstract

<p>Supplementary sections, including additional Materials and Methods, as well as Results and Tables. Table S1. SN-38 and SN-38G standard curves using triplicate dilutions of each concentration with single HPLC run. Table S2. SN-38 extraction efficiency. Table S3. Area under the curve (AUC) analysis of various products in the serum of nude mice given irinotecan or IMMU-132. Table S4. In vitro glucuronidation assay. Table S5. Analysis of products in the large intestine of animals given irinotecan or IMMU-132 (Study 2). Values represent the mean {plus minus} SD (N = 3) and are expressed in µg.</p>