Supplementary Figure S1. FGFR1 protein expression and FGFR1 gene copy-numbers in HPV-positive and HPV-negative head and neck squamous cell carcinoma. from FGFR1 Is a Potential Prognostic Biomarker and Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Abstract

<p>(A) FGFR1 protein overexpression and low FGFR1 expression in HPV-positive and HPV-negative head and neck squamous cell carcinoma patients. FGFR1 protein was overexpressed in 82% of HPV-positive and 75% of HPV-negative head and neck squamous cell carcinoma. (B) FGFR1 gene copy-numbers in HPV-positive and HPV-negative head and neck squamous cell carcinoma patients. 3% of FGFR1-overexpressing HPV-negative head and neck squamous cell carcinoma had FGFR1 amplification, 5% had a copy-number gain and 92% had normal gene copy-numbers. All FGFR1-overexpressing HPV-positive head and neck squamous cell carcinoma had normal FGFR1 gene copy-numbers. (C) The Kaplan-Meier overall survival curve for FGFR1 protein overexpression shows no relationship with survival for HPV-positive head and neck squamous cell carcinoma patients (FGFR1 overexpression: 7/33 events, low FGFR1 expression: 2/8 events). Overall survival time was missing for one patient, tissue microarray cores were unavailable for one tumor and two patients were excluded from survival analysis because they were treated with palliative intent. (D) The Kaplan-Meier disease-free survival curve also shows no relationship with survival for HPV-positive head and neck squamous cell carcinoma (FGFR1 overexpression: 10/33 events, low FGFR1 expression: 1/7 events). Disease-free survival time was missing for two patients, tissue microarray cores were unavailable for one tumor and two patients were excluded from survival analysis because they were treated with palliative intent.</p>