Supplementary Figure 4 from A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition

Abstract

<p>Supplementary Figure 4 PDF file - 38K, Identification of human melanoma and colorectal cancer cell lines with coincident B-RAF and NF1 mutations is associated with resistance to PLX4720. Human melanoma and colorectal cancer cell lines from the Cancer Cell Line Encyclopedia with B-RAFV600E and NF1 mutation were identified and compared to NF1 wild-type melanoma cell lines in terms of sensitivity to PLX4720, NF1 mRNA expression, NF1 copy number alterations and NF1 mutation status. In the heat map, blue represents lower values and red represents higher values, whilst NF1 mutation status is represented as wild-type: blue, point mutation: white, potential loss-of-function mutation: red</p>