Supplementary Figure 1 from Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer

Abstract

<p>PDF file - 248K, Supplementary Figure 1. (A) Simplified schematic of mucin type O-glycans analyzed in this report. Mucin-type O-linked glycans are initiated by the addition of an N-acetyl galactose sugar residue (the Tn epitope), which can be extended into the T antigen or core 3 structures, or Tn can be sialylated creating terminal STn that cannot be further extended. T antigen can be extended into core 2 structures that lead to the Lewis Blood Group antigens - LeX, SLeX, SLeC and sialyl Lewis A (the CA19-9 antigen, a widely utilized biomarker of adenocarcinoma progression). B & C - Representative immunohistochemical results for comparison of expression of mucin core proteins, glycans, and glycopeptides taken at 200x magnification. (B) Serial sections of primary tumor from autopsy patient 3 stained for indicated antigens. (C) Serial sections of liver metastasis from autopsy patient 20 for same antigens seen in primary tumor.</p>