Abstract
<p>Histological characterization of GEMM tumor model and PARPi-FL localization. (a) The GEMM model showed heterogenous morphological characteristics, representing high grade areas (with necrotic features, high cellularity, microvascular proliferation) and lower grade areas (less cellular, no necrosis). PARP1 expression was more pronounced in high grade areas compared to low grade areas and very low in normal pons. (b) Immunofluorescent characterization of high grade and low grade tumor areas and healthy brain. Tissues were stained for Ki67, CD31 and PARP1 expression. This was compared to the localization of intravenously in vivo injected PARPi-FL.</p>
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