Abstract
This study was aimed to find out the supplemental value of topiramate therapy in infraorbital nerve paresthesia following post miniplate fixation of zygomatic complex fracture. Total four cases of unilateral zygomatic complex fracture which were one week old had infra orbital nerve paresthesia were treated. All the patients were treated with fracture reduction and miniplate fixation of zygomatic buttress region were supplemented with tab topiramate in therapeutic dosages. The dosages were increased depending upon tolerability and improvement. Functional recovery was observed postoperatively from first week and complete recovery was within three months of treatment. Conclusion: We suggest that topiramate could be a useful supplemental form in the treatment of infra orbital nerve injury. Further studies (Double-blind) are needed with precise neurological examination to determine the recommendations of topiramate supplementation.
Highlights
Zygomatico-orbital fractures are one of the most common facial injuries
Smith-Swintosky et al [4] claimed that topiramate helps in nerve regrowth and enhances the recovery of facial nerve function after injury when administered orally in therapeutically relevant doses, and significantly increases neurite outgrowth in cell cultures derived from fetal rat cortical and hippocampal tissues [5]
The purpose of this study was to find out the supplemental value of topiramate therapy in post miniplate fixation of zygomatic complex fracture
Summary
Zygomatico-orbital fractures are one of the most common facial injuries. Sakavicious et al reported 64.4% incidence of infra orbital nerve injury in zygomatic-complex fracture [1]. Other studies [3] reported that the incidence of sensory disturbances in ZC fractures ranged from 30 to 80%. The surgical management of infra orbital nerve injury requires decompression of nerve by reduction of zygomatic complex fracture and sometime mobilization of nerve surrounding soft tissue which helps in early recovery of sensory function. Smith-Swintosky et al [4] claimed that topiramate helps in nerve regrowth and enhances the recovery of facial nerve function after injury when administered orally in therapeutically relevant doses, and significantly increases neurite outgrowth in cell cultures derived from fetal rat cortical and hippocampal tissues [5]. The purpose of this study was to find out the supplemental value of topiramate therapy in post miniplate fixation of zygomatic complex fracture
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