Supplemental Tables 1-5 and Figures 1-2 from Increased and Mistimed Sex Hormone Production in Night Shift Workers

Abstract

<p>Supplemental Tables 1-5 and Figures 1-2. Supplemental Table 1. Inter-assay precision of the GC-MS method for each sex hormone calculated as the coefficient of variation (CV) after analyzing 15 replicates (3 replicates in 5 different days). Supplemental Table 2. Estimated geometric mean (GM), geometric mean ratio ratio (GMR) and 95% confidence interval (CI) of 24-h mean metabolite levels (mesor) and peak time (acrophase) in night workers compared to day workers in premenopausal women (n=32) by menstrual cycle. Supplemental Table 3. Peak time (acrophase) of metabolite production (hh:mm) in day and night workers among men and women (geometric mean (GM) and 95% confidence intervals (CI)) Supplemental Table 4. Correlations between 6-sulfatoxymelatonin (aMT6s) and sex hormone 24-h mean levels (mesor) and peak time (acrophase) in all subjects, men and women (Pearson correlation coefficients). Supplemental Table 5. Correlations between 6-sulfatoxymelatonin (aMT6s) and sex hormones 24-h mean levels (mesor) and peak time (acrophase) in all, day and night workers (Pearson correlation coefficients). Supplemental Figure 1. Directed acyclic graph (DAG) used for the selections of confounders for the association between night shift work and urinary sex steroid metabolites. Supplemental Figure 2. Scatterplots and correlation coefficients (r) between log-tranformed 24-h mean levels (mesor) and peak time (acrophase) of 6-sulfatoxymelatonin and estradiol, estrone, pregnanediol and testosterone in men and women.</p>