Abstract
<p>Supplemental Figure S1. Spectral characteristics of UVA 340 lamps. Figure S2. Nrf2 disruption leads to an increase in the mRNA of Nrf3, but not Nrf1, in skin of SKH-1 hairless mice. Figure S3. TBE-31 treatment induces NQO1 in dermis and epidermis of WT SKH-1 hairless mice, but has no effect in Nrf2-KO animals. Figure S5. The architecture of the skin is similar among WT, Nrf2-KO and Keap1-KD SKH-1 hairless mice. Figure S6. Dose optimization for the use of TBE-31 as a pharmacological agent for protection against cutaneous carcinogenesis mediated by solar-simulated UV radiation. Figure S7. Optimization of azathioprine treatment in SKH-1 hairless mice. Figure S8. HPLC analysis of the sulforaphane (SF, active)- and glucoraphanin (GR, placebo) extracts used in the human study. Figure S9. NQO1 inducer activity of the sulforaphane (SF, active)- and glucoraphanin (GR, placebo) extracts used in the human study.</p>
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