Supplemental Figures and Tables from Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer

Abstract

<p>Supplemental Figure 1. Patient inclusion and exclusion criteria. TNBC: triple negative breast cancer; ALC: absolute lymphocyte count; nSES: neighborhood socioeconomic status. Supplemental Figure 2a and 2b. Association between minimum lymphocyte count (as percentage of total white blood cell count and absolute value) and stromal tumor infiltrating lymphocytes (sTILs), N=77. Figure 2a. sTILs were correlated with minimum % lymphocyte (p=0.02). Figure 2b. sTILs did not have a significant correlation with minimum absolute (abs) lymphocytes (p=0.36) Supplemental Figure 3. Comparison between Absolute Lymphocyte Count (ALC) and percent peripheral lymphocytes Supplemental Figure 4. Distribution of Absolute Lymphocyte Count (ALC) measures at baseline, defined as ALC value measured within the first three months of breast cancer diagnosis. Supplemental Figure 5. Distribution of minimum Absolute Lymphocyte Count (ALC) values at any time point Supplemental Figure 6. Distribution of overall minimum Absolute Lymphocyte Count (ALC) over time Supplemental Table 1. Multivariable analysis of predictors of lymphopenia (absolute lymphocyte count [ALC] <1K/�L; n=747); statistically significant variables are in bold font. Supplemental Table 2. Multivariable analysis of the association between minimum absolute lymphocyte count (ALC) and breast cancer-specific mortality using complete case analysis (n=747) †Supplemental Table 3. Multivariable analysis of the association between minimum absolute lymphocyte count (ALC) and breast cancer-specific mortality using multiple imputation methods Supplemental Table 4. Multivariable analysis of the association between minimum ALC and OM with RT temporal consideration (n=747) Supplemental Table 5. Multivariable analysis of the association between minimum ALC and BCM with RT temporal consideration (n=747) Supplemental Table 6. Multivariable analysis of the association between minimum ALC and OM with neutropenia temporal consideration (n=747) Supplemental Table 7. Multivariable analysis of the association between minimum ALC and BCM with neutropenia temporal consideration (n=747) Supplemental Table 8. Multivariable analysis of the association between minimum percent lymphocyte count and overall mortality using complete case analysis (n=532). Supplemental Table 9. Multivariable analysis of the association between minimum percent lymphocyte count and breast-cancer specific mortality using complete case analysis (n=532)</p>