Abstract

<p>Caffeic acid attenuates EGF-induced cell transformation. A, caffeic acid is not toxic to HaCaT cells. Cells were treated with caffeic acid (0-80 µmol/L) or its vehicle, DMSO (as a negative control) in 10% FBS/DMEM for 24 or 48 h. Cell viability was determined by MTS assay and data are represented as means {plus minus} S.D. No significant difference was observed between any groups. B, caffeic acid inhibits EGF-induced neoplastic transformation of HaCaT cells. Data are shown as means {plus minus} S.D from 3 independent experiments and the asterisk indicates a significant (*p < 0.05) decrease in colony formation in cells treated with caffeic acid compared with the DMSO-treated group.</p>

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